An Approach To Identification Of Dynamic Model For Optimization Of Fed-Batch Fermentation Processes

Donatas Levišauskas, Tomas Tekorius


A computation procedure is developed for identification of dynamic model intended for solving the biomass growth-related optimization problems at fed-batch fermentation processes. The model identification relies on exploiting a versatile structure model that covers several particular structure models commonly used in bioprocess engineering practice. The model parameters are found by using experimental data of batch or fed-batch fermentation processes and a consecutive identification procedure, which include the parameters preliminary estimation. Practical application of the proposed model identification procedure is demonstrated for solving the feed-rate optimization problem in fed-batch culture E.coli.



model identification; optimization; fed-batch fermentation process

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